Sexual dimorphism and age dependence of osteocyte lacunar density for human vertebral cancellous bone.
نویسندگان
چکیده
The sexual dimorphism in age-related loss of human vertebral cancellous bone is not fully understood and could be related to dimorphism in the bone cell populations. The objective of this study was to investigate age- and gender-related differences in the osteocyte population and its relationship with bone volume fraction for human vertebral cancellous bone. Histomorphometric techniques were used to quantify osteocyte lacunae (a measure of osteocyte population) and bone volume fraction in male and female human T12 vertebrae, the most common site of vertebral fracture. Two measures of osteocyte population [number of osteocytes per bone area (OtLcDn) and number of osteocytes per total area (OtLcN/TA)] and their relationships with age and bone volume fraction were found to be sexually dimorphic. Dimorphism in osteocyte density may explain the dimorphic patterns of bone loss in human vertebrae due to the sensory and signal communication functions that osteocytes perform.
منابع مشابه
0702 - Age-dependence of Osteocyte Lacunar Density Is Sexually Dimorphic in Human Vertebral Cancellous Bone
INTRODUCTION Human vertebral cancellous bone is one of the primary sites for age-related bone loss. In aging females bone loss occurs due to an increased rate of resorption while in males, bone loss results from a decline in bone formation rate (1). This sexual dimorphism in the mechanism of bone loss may be a consequence of the changes in endocrine, paracrine and autocrine factors which regula...
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عنوان ژورنال:
- The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
دوره 282 2 شماره
صفحات -
تاریخ انتشار 2005